Association study between SNP rs150689919 in the DNA demethylation gene, TET1, and Parkinson’s disease in Chinese Han populationReport as inadecuate




Association study between SNP rs150689919 in the DNA demethylation gene, TET1, and Parkinson’s disease in Chinese Han population - Download this document for free, or read online. Document in PDF available to download.

BMC Neurology

, 13:196

Movement disorders

Abstract

BackgroundRecent studies suggest that epigenetic factors may play an important role in the pathogenesis of Parkinson’s disease PD. In our previous work, we sequenced the exomes of sixteen patients from eight Chinese PD families using whole exome sequencing technology, consequently three patients from different pedigrees were found sharing the variant c.1460C > T rs150689919 in the coding region of the Tet methyl cytosine dioxygenase 1 TET1 gene.

MethodsIn order to evaluate the possible association between sporadic PD and the single nucleotide polymorphism SNP rs150689919 in TET1, a case–control cohort study was conducted in 514 sporadic PD patients and 529 normal controls. Genotyping was determined by PCR and direct sequencing. Statistical significance was analyzed by the Chi-squared test.

ResultsThere was no statistical significance in TET1 rs150689919 genotype or allele frequencies between the PD cases and healthy controls, even after being stratified by gender and age at onset.

ConclusionsOur findings suggest that rs150689919 in TET1 may not be associated with PD in Chinese population. However, due to the limited data in this study, replication studies in larger sample and other populations are required.

KeywordsTET1 Parkinson’s disease Epigenetics Chinese AbbreviationsPDParkinson’s disease

TET1Tet methyl cytosine dioxygenase 1 gene

SNCAAlpha-synuclein gene

PARK16Parkinson disease 16

EOPDEarly onset Parkinson’s disease

LOPDLate Onset Parkinson’s disease

PCRPolymerase chain reaction

dfdegree of freedom

OROdds ratio

GWASGenome-wide association studies.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2377-13-196 contains supplementary material, which is available to authorized users.

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Author: Xin-xin Liao - Zi-xiong Zhan - Ying-ying Luo - Kai Li - Jun-ling Wang - Ji-feng Guo - Xin-xiang Yan - Kun Xia - Bei-sha T

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