A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reachedReport as inadecuate




A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached - Download this document for free, or read online. Document in PDF available to download.

European Journal of Nutrition

, Volume 51, Issue 6, pp 665–675

First Online: 28 September 2011Received: 26 April 2011Accepted: 07 September 2011

Abstract

PurposeHigher long-chain polyunsaturated fatty acids LCP in infant compared with maternal lipids at delivery is named biomagnification. The decline of infant and maternal docosahexaenoic acid DHA status during lactation in Western countries suggests maternal depletion. We investigated whether biomagnification persists at lifelong high fish intakes and whether the latter prevents a postpartum decline of infant and-or maternal DHA status.

MethodsWe studied 3 Tanzanian tribes with low Maasai: 0-week, intermediate Pare: 2–3-week, and high Sengerema: 4–5-week fish intakes. DHA and arachidonic acid AA were determined in maternal m and infant i erythrocytes RBC during pregnancy 1st trimester n = 14, 2nd = 103, 3rd = 88, and in mother–infant pairs at delivery n = 63 and at 3 months postpartum n = 104.

ResultsAt delivery, infants of all tribes had similar iRBC-AA which was higher than, and unrelated to, mRBC-AA. Transplacental DHA biomagnification occurred up to 5.6 g% mRBC-DHA; higher mRBC-DHA was associated with -bioattenuation- i.e., iRBC-DHA < mRBC-DHA. Compared to delivery, mRBC-AA after 3 months was higher, while iRBC-AA was lower. mRBC-DHA after 3 months was lower, while iRBC-DHA was lower low fish intake, equal intermediate fish intake, and higher high fish intake compared to delivery. We estimated that postpartum iRBC-DHA equilibrium is reached at 5.9 g%, which corresponds to a mRBC-DHA of 6.1 g% throughout pregnancy.

ConclusionUniform high iRBC-AA at delivery might indicate the importance of intrauterine infant AA status. Biomagnification reflects low maternal DHA status, and bioattenuation may prevent intrauterine competition of DHA with AA. A mRBC-DHA of about 6 g% during pregnancy predicts maternal–fetal equilibrium at delivery, postnatal iRBC-DHA equilibrium, but is unable to prevent a postnatal mRBC-DHA decline.

KeywordsBiomagnification Bioattenuation Pregnancy Long-chain polyunsaturated fatty acids Docosahexaenoic acid Arachidonic acid Equilibrium Martine F. Luxwolda and Remko S. Kuipers contributed equally to this paper.

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Author: Martine F. Luxwolda - Remko S. Kuipers - Wicklif S. Sango - Gideon Kwesigabo - D. A. Janneke Dijck-Brouwer - Frits A. 

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