Seprafilm® adhesion barrier: 2 a review of the clinical literature on intraabdominal useReport as inadecuate




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Gynecological Surgery

, Volume 9, Issue 3, pp 247–257

First Online: 15 April 2012Received: 18 January 2012Accepted: 08 February 2012

Abstract

This study seeks to provide a review of the clinical data published as of July 2011 concerning the postsurgical adhesion barrier, Seprafilm chemically modified hyaluronic acid and carboxymethylcelulose; Genzyme Corporation, Cambridge, MA. Included articles detail the application of Seprafilm for intraabdominal uses that have been approved on-label and those considered investigational off-label by the FDA. Medline and EMBASE Drugs and Pharmaceuticals databases were searched for all original clinical Seprafilm research published as of July 2011. All human Seprafilm intraabdominal clinical reports and studies, excluding those related to prosthetic mesh were included. Data extraction involved the systematic review of each article. The data synthesis is the summary of Seprafilm human intraabdominal clinical reports and studies describing safety and-or efficacy. The safety and efficacy of Seprafilm in reducing postoperative adhesions has been clearly demonstrated in abdominal and pelvic laparotomy. While reports have described the safe and successful use of Seprafilm following laparoscopy, pediatric laparotomy, and in patients with malignancy and-or infection, the safety and efficacy of Seprafilm use in these procedures has not been definitively established in randomized controlled trials.

KeywordsPostoperative adhesions Seprafilm Anti-adhesion adjuvant Adhesiolysis Declaration of interestMichael P. Diamond has acted as consultant to the company. The authors alone are responsible for the content and writing of the paper.

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Author: Michael P. Diamond - Ellen L. Burns - Beverly Accomando - Sadiqa Mian - Lena Holmdahl

Source: https://link.springer.com/







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