An un-commissioned randomized, placebo-controlled double-blind study to test the effect of deep sea fish oil as a pain reliever for dogs suffering from canine OAReport as inadecuate




An un-commissioned randomized, placebo-controlled double-blind study to test the effect of deep sea fish oil as a pain reliever for dogs suffering from canine OA - Download this document for free, or read online. Document in PDF available to download.

BMC Veterinary Research

, 8:157

Pharmacology and toxicology

Abstract

BackgroundAn un-commissioned randomized, double-blinded, placebo controlled clinical study was planned using a deep sea fish oil product for pets. Seventy-seven client-owned dogs with osteoarthritis were randomly assigned to supplement the food with either the fish oil product or corn =placebo oil. Our main outcome variables were force platform variables peak vertical force PVF and impulse, the validated Helsinki Chronic Pain Index HCPI and the use of rescue NSAIDs. Secondary outcome variables were a locomotion visual analog scale VAS, a Quality of life VAS, a comparative questionnaire, a veterinary assessment, owners’ final assessment of outcome and guessing the product given.

ResultsWhen comparing the two test groups at the end of the trial 16 weeks there was no significant difference in any of the main outcome variables but owners of dogs that had taken fish oil were significantly happier with the treatment at the end visit and did significantly better at guessing what group their dogs had been in, compared to the placebo group. When comparing variables within the fish oil group as change from baseline to trial end, there were significant positive changes in PVF, HCPI, NSAID use, Quality of life VAS, as well as in all three scores in the comparative questionnaire locomotion, every-day situations, and skin and coat. There were similar positive trends in force platform impulse and in the veterinary assessment variables, although they did not reach significance. Within the placebo group there were significant positive changes only in the HCPI and a significant deterioration according to veterinary assessment.

ConclusionsWhen compared to placebo, there was not a major statistically significant benefit in using deep sea fish oil as a pain reliever in our study population of dogs suffering from osteoarthritis. However, the fish oil treated patients improved significantly in many of the variables, when comparing baseline values to the study-end values within the group, indicating a true but small relief in symptoms. Deep sea fish oil supplementation could be considered a part of the multimodal pain relieving approach currently recommended for dogs suffering from OA, especially for individuals that do not tolerate anti-inflammatory drugs.

KeywordsOsteoarthritis Pain Fish oil Omega-3 Fatty acid Canine - Dog Supplement Joint RCT Double-blind AbbrevationsAAArachidonic acid, an ω-6 FA

ALAα-linolenic acid, an ω-3 FA

ANCOVAAnalysis of covariance

ANOVAAnalysis of variance

BWBody weight

CHDCanine hip dysplasia

CONSORTConsolidated standards of reporting trials

DHADocosahexaenoic acid

DPADocosapentaenoic acid, an ω-3 FA

EDElbow dysplasia

EFAEssential fatty acids

EPAEicosapentaenoic acid

ETAEicosatetraenoic acid, an ω-3 FA

FAFatty acid

HCPIHelsinki Chronic Pain Index

MMPMatrix metalloproteinase

NSAIDNon-steroidal anti-inflammatory drug

OAOsteoarthritis

ωOmega

PVFPeak vertical force

QOLQuality of life

RARheumatoid arthritis

RCTRandomized clinical trial

RMANCOVARepeated measures analysis of variance

SDStandard deviation

TIMPTissue inhibitor metalloproteinase

VASVisual analog scale

W-xx weeks before baseline

W0Baseline

Wxx weeks after baseline.

Electronic supplementary materialThe online version of this article doi:10.1186-1746-6148-8-157 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Anna Hielm-Björkman - Johanna Roine - Kari Elo - Anu Lappalainen - Jouni Junnila - Outi Laitinen-Vapaavuori

Source: https://link.springer.com/







Related documents