How to improve drug dosing for patients with renal impairment in primary care - a cluster-randomized controlled trialReport as inadecuate




How to improve drug dosing for patients with renal impairment in primary care - a cluster-randomized controlled trial - Download this document for free, or read online. Document in PDF available to download.

BMC Family Practice

, 13:91

Epidemiology and research methodology in primary care

Abstract

BackgroundPatients with chronic kidney disease CKD are at increased risk for inappropriate or potentially harmful prescribing. The aim of this study was to examine whether a multifaceted intervention including the use of a software programme for the estimation of creatinine clearance and recommendation of individual dosage requirements may improve correct dosage adjustment of relevant medications for patients with CKD in primary care.

MethodsA cluster-randomized controlled trial was conducted between January and December 2007 in small primary care practices in Germany. Practices were randomly allocated to intervention or control groups. In each practice, we included patients with known CKD and elderly patients ≥70 years suffering from hypertension. The practices in the intervention group received interactive training and were provided a software programme to assist with individual dose adjustment. The control group performed usual care. Data were collected at baseline and at 6 months. The outcome measures, analyzed across individual patients, included prescriptions exceeding recommended maximum daily doses, with the primary outcome being prescriptions exceeding recommended standard daily doses by more than 30%.

ResultsData from 44 general practitioners and 404 patients are included. The intervention was effective in reducing prescriptions exceeding the maximum daily dose per patients, with a trend in reducing prescriptions exceeding the standard daily dose by more than 30%.

ConclusionsA multifaceted intervention including the use of a software program effectively reduced inappropriately high doses of renally excreted medications in patients with CKD in the setting of small primary care practices.

Trial registrationCurrent Controlled Trials ISRCTN02900734

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2296-13-91 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Antje Erler - Martin Beyer - Juliana J Petersen - Kristina Saal - Thomas Rath - Justine Rochon - Walter E Haefeli - Ferdi

Source: https://link.springer.com/







Related documents