Therapeutic imprinting of the immune system: towards a remission of AIDS in primatesReport as inadecuate




Therapeutic imprinting of the immune system: towards a remission of AIDS in primates - Download this document for free, or read online. Document in PDF available to download.

Retrovirology

, 9:75

First Online: 14 September 2012Received: 10 July 2012Accepted: 02 September 2012

Abstract

Our inability to cure HIV-AIDS is related to the ability of the virus to establish reservoirs during treatment. In order to develop new strategies, it is certainly essential that a suitable animal model be implemented. In the recent work of Shytaj et al., it has been possible to inhibit viral replication to levels below the assay detection limit in the macaque AIDS model. Moreover, different therapeutic regimens applied to the rhesus macaque AIDS model herein reviewed, including ours, are starting to show the potential to induce, following therapy suspension, conditions reminiscent of a drug-free control of the infection.

KeywordsMacaque AIDS model Functional cure Antiretroviral therapy Central memory CD4 T-cells Maraviroc Auranofin Buthionine sulfoximine BSO Anti-reservoir Electronic supplementary materialThe online version of this article doi:10.1186-1742-4690-9-75 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Andrea Savarino - Enrico Garaci

Source: https://link.springer.com/







Related documents