Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systemsReport as inadecuate




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Diagnostic Pathology

, 7:120

First Online: 14 September 2012Received: 16 June 2012Accepted: 10 August 2012

Abstract

BackgroundTo evaluate the expression and differential significance of c-Jun, p73, Casp-9 and N-ras in thymic epithelial tumors TETs with the aim to provide useful information for tumor biology and prospective therapy.

MethodsIn this study, we analyzed the expression of four chromosome 1-related genes, namely c-Jun, p73, Casp-9 and N-ras, in 60 cases of thymic epithelial tumors. The tumors included 52 thymomas and 8 thymic carcinomas which were categorized according to the current WHO classification systems.

ResultsCompared with the normal thymus tissue, all thymic epithelial tumors demonstrated higher expression of c-Jun and p73. The expression of c-Jun and p73 in type B2, B3 thymoma and thymic carcinomas was similar, and significantly higher than that in all other subtypes of thymomas. Unlike type A thymoma, the expression of Casp-9 was relatively lower in type B thymoma and thymic carcinomas. With respect to the clinical staging systems, c-Jun was more expressed in progressive tumors harboring higher stages. In contrast to c-Jun, p73 and Casp-9, there was no significant aberration with N-ras expression irrespective of either tissue or tumor types.

ConclusionsThe overexpression of c-Jun, p73 and Casp-9 in thymic epithelial tumors is closely related with the pathogenesis and biological behavior of the neoplasms. These candidate biomarkers provided useful information for prospective personalized therapy in the clinical management.

Additional non-English language abstract language: Chinese背景:评估c-Jun, p73, Casp-9 和 N-ras在胸腺上皮性肿瘤诊断和鉴别诊断中的运用.

方法:根据世界卫生组织最新的诊断标准60例胸腺上皮性肿瘤分类,运用Envision法检测c-Jun,p73,Casp-9 和N-ras在不同亚型肿瘤中的表达情况,并结合临床病理学特征进行分析.

结果:c-Jun和p73在肿瘤中的表达明显高于正常胸腺组织;c-Jun和p73在B3,B2型胸腺瘤和胸腺癌的表达类似,且表达明显高于其他类型的胸腺肿瘤;Caspase-9在B型胸腺瘤和胸腺癌中的表达相对低于A型胸腺瘤;c-Jun的表达更常见于高级别的胸腺肿瘤.

结论:c-Jun,p73和Casp-9在胸腺肿瘤中的表达很好地反映了肿瘤的生物学特点,为胸腺肿瘤的诊断和鉴别诊断提供了较好的理论基础.

Virtual Slideshttp:-www.diagnosticpathology.diagnomx.eu-vs-1521774814749726

KeywordsThymic tumour Histologic classification World Health Organization WHO c-Jun p73 Casp-9 N-ras AbbreviationsTETsThymic epithelial tumors

WHOWorld health organization

FFPEFormaldehyde-fixed, paraffin-embedded.

Electronic supplementary materialThe online version of this article doi:10.1186-1746-1596-7-120 contains supplementary material, which is available to authorized users.

Yuqing Ma, Qiaoxin Li contributed equally to this work.

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Author: Yuqing Ma - Qiaoxin Li - Wenli Cui - Na Miao - Xia Liu - Wei Zhang - Chen Zhang - Jian Wang

Source: https://link.springer.com/







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