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Transplantation Research

, 1:14

Myeloid suppressor cell therapy

Abstract

Dendritic cells DCs are critically involved in inducing either immunity or tolerance. During the last decades efforts have been devoted to the development of ad hoc methods to manipulate DCs in vitro to enhance or stabilize their tolerogenic properties. Addition of IL-10 during monocyte-derived DC differentiation allows the induction of DC-10, a subset of human tolerogenic DCs characterized by high IL-10-IL-12 ratio and co-expression of high levels of the tolerogenic molecules HLA-G and immunoglobulin-like transcript 4. DC-10 are potent inducers of adaptive type 1 regulatory T cells, well known to promote and maintain peripheral tolerance. In this review we provide an in-depth comparison of the phenotype and mechanisms of suppression mediated by DC-10 and other known regulatory antigen-presenting cells currently under clinical development. We discuss the clinical therapeutic application of DC-10 as inducers of type 1 regulatory T cells for tailoring regulatory T-cell-based cell therapy, and the use of DC-10 as adoptive cell therapy for promoting and restoring tolerance in T-cell-mediated diseases.

KeywordsIL-10 Dendritic cells Tolerance Type 1 regulatory T cells Regulatory Antigen-Presenting Cells AbbreviationsAgantigen

APCantigen-presenting cell

DCdendritic cell

IDOindoleamine-2,3-dioxigenase

FOXP3forkhead box P3

G-CSFgranulocyte colony-stimulating factor

GM-CSFgranulocyte–macrophage colony-stimulating factor

GMPgood manufacturing practice

HO-1heme oxygenase-1

IFNinterferon

ILinterleukin

ILTimmunoglobulin-like transcript

M-CSFmacrophage colony-stimulating factor

RAPArapamycin

TGFtransforming growth factor

TNFtumor necrosis factor

Tr1type 1 T regulatory

Tregregulatory T cell.

Electronic supplementary materialThe online version of this article doi:10.1186-2047-1440-1-14 contains supplementary material, which is available to authorized users.

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Author: Giada Amodio - Silvia Gregori

Source: https://link.springer.com/



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