Immunophenotype characteristics of peripheral blood mononuclear leukocytes of chronic idiopathic urticaria patients. Report as inadecuate




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Mercedes Zabaleta ; Oscar Aldrey ; Henry Rivera ; Juan B. De Sanctis ; Nicolás E. Bianco ; Isaac Blanca ;Investigación Clínica 2006, 47 4

Author: Jenny V. Garmendia

Source: http://www.redalyc.org/articulo.oa?id=372937665005


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Investigación Clínica ISSN: 0535-5133 riclinicas@gmail.com Universidad del Zulia Venezuela Garmendia, Jenny V.; Zabaleta, Mercedes; Aldrey, Oscar; Rivera, Henry; De Sanctis, Juan B.; Bianco, Nicolás E.; Blanca, Isaac Immunophenotype characteristics of peripheral blood mononuclear leukocytes of Chronic Idiopathic Urticaria patients. Investigación Clínica, vol.
47, núm.
4, 2006, pp.
361-369 Universidad del Zulia Maracaibo, Venezuela Available in: http:--www.redalyc.org-articulo.oa?id=372937665005 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Invest Clin 47(4): 361 - 369, 2006 Immunophenotype characteristics of peripheral blood mononuclear leukocytes of Chronic Idiopathic Urticaria patients. Jenny V.
Garmendia, Mercedes Zabaleta, Oscar Aldrey, Henry Rivera, Juan B.
De Sanctis, Nicolás E.
Bianco e Isaac Blanca. Instituto de Inmunología, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.
E-mail: garmmenj@ucv.ve Key words: Urticaria, cell immunophenotype, memory cells. Abstract.
The pathogenesis of chronic idiopathic urticaria (CIU) is not completely understood although autoimmunity has been proposed.
The aim of the study was to assess the expression of different leukocyte antigens, by flow cytometry, assaying total blood of 29 patients with CIU and of 20 sex and age matched controls.
Moreover, we assessed soluble CD154 a marker of immune cell activation, predominantly memory T cells.
When patients were divided depending an their response to the autologous serum skin test (ASST), three different groups were encountered: group 1 (n = 11): with negative ASST –, group 2 (n = 11): positive ASST (ASST ) with normal lymphocyte counts and group 3 (n = 7): ASST with low lymphocyte counts ( 1500 cells-...





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