Investigation of Physical Properties of a Polycaprolactone Dermal Filler when Mixed with Lidocaine and Lidocaine-EpinephrineReport as inadecuate




Investigation of Physical Properties of a Polycaprolactone Dermal Filler when Mixed with Lidocaine and Lidocaine-Epinephrine - Download this document for free, or read online. Document in PDF available to download.

Dermatology and Therapy

, 2:13

First Online: 28 September 2012Received: 16 August 2012

Abstract

IntroductionIn esthetic treatments with dermal fillers, increasing numbers of physicians are using the technique of mixing an anesthetic agent into the dermal filler before treatment to increase the comfort of the patients. This study aimed at evaluating the effects on the physical properties of a polycaprolactone PCL-based dermal filler after mixing with lidocaine.

MethodsA range of 2.0% lidocaine and 2.0% lidocaine-epinephrine concentrations was mixed with the PCL dermal filler to evaluate the changes in dynamic viscosity and elasticity, extrusion force, pH, and needle jam rates. The number of passes back to forth for optimal homogeneity of lidocaine and PCL dermal filler was determined.

ResultsWith 15 mixing strokes the lidocaine solution can effectively be mixed into dermal filler resulting in a homogenous blend. The viscosity, elasticity, and the extrusion force decrease with increasing lidocaine volume. The viscosity and elasticity of the dermal filler is sufficient to keep the PCL microspheres in suspension. There were no needle jams. The pH of the PCL dermal filler mixed with lidocaine solution is equivalent to that of the original dermal filler.

ConclusionIt is concluded that mixing of lidocaine into the PCL-based dermal filler can safely be performed without harmful changes in the physical properties of the original dermal filler.

KeywordsCarboxymethylcellulose Dermal filler Dermatology Elasticity Esthetic treatment Lidocaine Polycaprolactone Viscosity  Download fulltext PDF



Author: Francisco de Melo - Joanna Marijnissen-Hofsté

Source: https://link.springer.com/







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