Fructose metabolism in humans – what isotopic tracer studies tell usReport as inadecuate




Fructose metabolism in humans – what isotopic tracer studies tell us - Download this document for free, or read online. Document in PDF available to download.

Nutrition and Metabolism

, 9:89

First Online: 02 October 2012Received: 03 August 2012Accepted: 24 September 2012

Abstract

Fructose consumption and its implications on public health are currently under study. This work reviewed the metabolic fate of dietary fructose based on isotope tracer studies in humans. The mean oxidation rate of dietary fructose was 45.0% ± 10.7 mean ± SD in non-exercising subjects within 3–6 hours and 45.8% ± 7.3 in exercising subjects within 2–3 hours. When fructose was ingested together with glucose, the mean oxidation rate of the mixed sugars increased to 66.0% ± 8.2 in exercising subjects. The mean conversion rate from fructose to glucose was 41% ± 10.5 mean ± SD in 3–6 hours after ingestion. The conversion amount from fructose to glycogen remains to be further clarified. A small percentage of ingested fructose <1% appears to be directly converted to plasma TG. However, hyperlipidemic effects of larger amounts of fructose consumption are observed in studies using infused labeled acetate to quantify longer term de novo lipogenesis. While the mechanisms for the hyperlipidemic effect remain controversial, energy source shifting and lipid sparing may play a role in the effect, in addition to de novo lipogenesis. Finally, approximately a quarter of ingested fructose can be converted into lactate within a few of hours. The reviewed data provides a profile of how dietary fructose is utilized in humans.

KeywordsFructose Glucose Isotope tracer Metabolism Electronic supplementary materialThe online version of this article doi:10.1186-1743-7075-9-89 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Sam Z Sun - Mark W Empie

Source: https://link.springer.com/



DOWNLOAD PDF




Related documents