Longterm melatonin administration alleviates paraquat mediated oxidative stress in drosophila melanogaster Report as inadecuate




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Milagros Paz ; Marylú Mora ; Ernesto Bonilla ; Yanauri Bravo ; José Luis Arcaya ; Raikelin Terán ; Virginia Villalobos ;Investigación Clínica 2014, 55 4

Author: Shirley Medina Leendertz

Source: http://www.redalyc.org/articulo.oa?id=372937033006


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Investigación Clínica ISSN: 0535-5133 riclinicas@gmail.com Universidad del Zulia Venezuela Medina Leendertz, Shirley; Paz, Milagros; Mora, Marylú; Bonilla, Ernesto; Bravo, Yanauri; Arcaya, José Luis; Terán, Raikelin; Villalobos, Virginia Longterm melatonin administration alleviates paraquat mediated oxidative stress in Drosophila melanogaster Investigación Clínica, vol.
55, núm.
4, diciembre, 2014, pp.
352-364 Universidad del Zulia Maracaibo, Venezuela Available in: http:--www.redalyc.org-articulo.oa?id=372937033006 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Invest Clin 55(4): 352 - 364, 2014 Longterm melatonin administration alleviates paraquat mediated oxidative stress in Drosophila melanogaster. Shirley Medina-Leendertz1, Milagros Paz3, Marylú Mora1, Ernesto Bonilla1,2, Yanauri Bravo1, José Luis Arcaya2, Raikelin Terán3 y Virginia Villalobos3. Laboratorio de Neurobiología, Centro de Investigaciones Biomédicas, Instituto Venezolano de Investigaciones Científicas, Hospital Universitario de Maracaibo, estado Zulia, Venezuela. 2Instituto de Investigaciones Clínicas “Dr.
Américo Negrette”, Facultad de Medicina. 3Departamento de Biología, Facultad Experimental de Ciencias. Universidad del Zulia.
Maracaibo, estado Zulia, Venezuela. 1 Keywords: paraquat, melatonin, reactive oxygen species, Drosophila melanogaster. Abstract.
We investigated the effect of melatonin (MEL) in the activities of cytosolic superoxide dismutase (SOD) and catalase as well as in the levels of H2O2 and mitochondrial malondialdehyde (MDA) in paraquat-intoxicated Drosophila melanogaster.
Paraquat (40 mM) was administrated for 36 h. Three groups of flies intoxicated with paraquat were used: PQ (exposed during 36h to paraquat), PQ-MEL (e...





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