Effect of autoimmune diseases on incidence and survival in subsequent multiple myelomaReport as inadecuate




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Journal of Hematology and Oncology

, 5:59

First Online: 02 October 2012Received: 03 September 2012Accepted: 26 September 2012

Abstract

BackgroundPatients with many types of autoimmune diseases AIDs are at an increased risk of cancer, which may depend on underlying dysregulation of the immune system or treatment. We systematically analyzed myeloma risk and survival in patients diagnosed with 33 different AIDs.

MethodsData on patients with AIDs were retrieved from the Swedish Hospital Discharge Register and were linked to myeloma diagnoses from the Cancer Registry. Standardized incidence ratios SIR and hazard ratios HRs were calculated for subsequent myeloma between 1964 and 2008.

ResultsAmong patients with the 33 AIDs analyzed, 457 cases of myeloma were diagnosed. The overall SIR for myeloma was 1.12 and the overall HR was 0.92 and non-significant. SIRs for myeloma were significantly increased after ankylosing spondylitis 2.02 and systemic sclerosis 2.63. Only the HR for myeloma after rheumatic fever 5.27 was significantly increased. The SIR for myeloma before age 60 years was 1.45; the SIR for myeloma was only increased in the period 1964–1990 1.31 and not later 1.04. Only the SIR for myeloma after ankylosing spondylitis was increased in the period 1991–2008 2.09; the HRs for myeloma were increased after polymyositis-dermatomyositis 6.44 and rheumatic fever 4.43 but there were only three deaths of myeloma after these AIDs.

ConclusionsThe present data showed an increase in myeloma SIR after two AIDs, ankylosing spondylitis and systemic sclerosis, and in HR after rheumatic fever. The overall myeloma risk after any AID was no longer increased in the latter follow-up period of 1991 through 2008.

KeywordsAutoimmune disease Multiple myeloma Incidence Survival  Download fulltext PDF



Author: Kari Hemminki - Xiangdong Liu - Asta Försti - Jianguang Ji - Jan Sundquist - Kristina Sundquist

Source: https://link.springer.com/







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