Comparative evaluation of flavone from Mucuna pruriens and coumarin from Ionidium suffruticosum for hypolipidemic activity in rats fed with high Fat dietReport as inadecuate




Comparative evaluation of flavone from Mucuna pruriens and coumarin from Ionidium suffruticosum for hypolipidemic activity in rats fed with high Fat diet - Download this document for free, or read online. Document in PDF available to download.

Lipids in Health and Disease

, 11:126

First Online: 02 October 2012Received: 06 July 2012Accepted: 29 September 2012

Abstract

The objective of the study is a comparative evaluation of flavone isolated from Mucuna pruriens and coumarin isolated from Ionidium suffruticosum was assessed for the hypolipidemic activity in rats fed with high fat diet. The acute toxicity study was found that flavone M.pruriens and coumarin I.suffruticosum are safe up to 100mg-kg, so one tenth of this dose 10mg-kg was consider as a evaluation dose. High fat diet group of rats showed significant p<0.001 elevation in plasma total and LDL-cholesterol, triglycerides and phospholipids. Administration of flavone M. pruriens and coumarin isolated from I.suffruticosum at the dose of 10mg-kg b.wt-day along with high fat diet significantly p<0.001 prevented the rise in the plasma total and LDL-cholesterol, triglycerides and phospholipids than that of other extracts. However, treatment of coumarin isolated from I.suffruticosum had showed more cardio protective effect against hyperlipidemia than that of flavone M.pruriens.

KeywordsM. pruriens I.suffruticosum Flavone Coumarin Hyperlipidemia  Download fulltext PDF



Author: Satheesh Kumar Dharmarajan - Kottai Muthu Arumugam

Source: https://link.springer.com/



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