A finite-element model for healing of cutaneous wounds combining contraction, angiogenesis and closureReport as inadecuate




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Journal of Mathematical Biology

, Volume 65, Issue 5, pp 967–996

First Online: 10 November 2011Received: 14 December 2010Revised: 07 June 2011

Abstract

A simplified finite-element model for wound healing is proposed. The model takes into account the sequential steps of dermal regeneration, wound contraction, angiogenesis and wound closure. An innovation in the present study is the combination of the aforementioned partially overlapping processes, which can be used to deliver novel insights into the process of wound healing, such as geometry related influences, as well as the influence of coupling between the various existing subprocesses on the actual healing behavior. The model confirms the clinical observation that epidermal closure proceeds by a crawling and climbing mechanism at the early stages, and by a stratification process in layers parallel to the skin surface at the later stages. The local epidermal oxygen content may play an important role here. The model can also be used to investigate the influence of local injection of hormones that stimulate partial processes occurring during wound healing. These insights can be used to improve wound healing treatments.

KeywordsWound healing Finite-element method Wound closure Wound contraction Angiogenesis Mathematics Subject Classification 200035L65 92C99  Download to read the full article text



Author: F. J. Vermolen - E. Javierre

Source: https://link.springer.com/







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