A new asymmetric synthesis of 2,6-cis-disubstituted-4-methylenpiperidines. Total synthesis of -alkaloid 241D and -isosolenopsin AReport as inadecuate




A new asymmetric synthesis of 2,6-cis-disubstituted-4-methylenpiperidines. Total synthesis of -alkaloid 241D and -isosolenopsin A - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 SEESIB - Synthèse et étude de systèmes à intêret biologique

Abstract : A highly diastereoselective synthesis of 2,6-cis-disubstituted-4-methylenepiperidines based on a Mannich type intramolecular cyclization of an allylsilane on an iminium ion is described. The synthetic potential of this methodology is demonstrated by the enantioselective synthesis of two natural piperidine alkaloids: +-alkaloid 241D and +-isosolenopsin A





Author: J. Monfray - Y. Gelas-Mialhe - J.-C. Gramain - R. Remuson -

Source: https://hal.archives-ouvertes.fr/



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