Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing - a cohort studyReport as inadecuate




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BMC Gastroenterology

, 12:159

First Online: 12 November 2012Received: 21 May 2012Accepted: 04 November 2012

Abstract

BackgroundInvasive techniques are still required to distinguish between uncomplicated and complicated forms of CD.

MethodsWe set out to investigate the potential use of novel serum parameters, including IL-6, IL-8, IL-17, IL-22, sCD25, sCD27, granzyme-B, sMICA and sCTLA-4 in patients diagnosed with active CD, CD on a GFD, Refractory coeliac disease RCD type I and II, and enteropathy associated T-cell lymphoma EATL.

ResultsIn both active CD and RCDI-II elevated levels of the proinflammatory IL-8, IL-17 and sCD25 were observed. In addition, RCDII patients displayed higher serum levels of soluble granzyme-B and IL-6 in comparison to active CD patients. In contrast, no differences between RCDI and active CD or RCDII were observed. Furthermore, EATL patients displayed higher levels of IL-6 as compared to all other groups.

ConclusionsA series of novel serum parameters reveal distinctive immunological characteristics of RCDII and EATL in comparison to uncomplicated CD and RCDI.

KeywordsCoeliac disease Refractory coeliac disease Enteropathy associated T-cell lymphoma Cytokines Immunological and biochemical parameters AbbreviationsACDActive coeliac disease

CDCoeliac disease

IELIntraepithelial lymphocyte

GFDGluten-free diet

RCDRefractory coeliac disease

EATLEnteropathy associated T-cell lymphoma.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-230X-12-159 contains supplementary material, which is available to authorized users.

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Author: Greetje J Tack - Roy L J van Wanrooij - B Mary E Von Blomberg - Hedayat Amini - Veerle M H Coupe - Petra Bonnet - Chr

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