Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German childrenReport as inadecuate




Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children - Download this document for free, or read online. Document in PDF available to download.

BMC Infectious Diseases

, 12:312

Bacterial and fungal diseases

Abstract

BackgroundAcute Otitis Media AOM is an important and common disease of childhood. Bacteria isolated from cases of clinically problematic AOM in German children were identified and characterized.

MethodsIn a prospective non-interventional study in German children between 3 months and less than 60 months of age with Ear, Nose and Throat Specialist –confirmed AOM, middle ear fluid was obtained by tympanocentesis when clinically indicated or by careful sampling of otorrhea through-at an existing perforation.

ResultsIn 100 children with severe AOM, Haemophilus influenzae was identified in 21% 18-21, 85.7% were non-typeable NTHi, Streptococcus pneumoniae in 10%, S. pyogenes in 13% and Moraxella catarrhalis in 1%. H. influenzae was the most frequently identified pathogen in children from 12 months of age. H. influenzae and S. pneumoniae were equally prevalent in children aged 3–11 months, but S. pyogenes was most frequently isolated in this age group. NTHi AOM disease appeared prevalent in all ages.

ConclusionsNTHi, S. pneumoniae and S. pyogenes are implicated as important causes of complicated AOM in children in Germany. NTHi disease appears prevalent in all ages. The impact of vaccination to prevent NTHi and S. pneumoniae AOM may be substantial in this population and is worth investigating.

Keywordsotitis media Streptococcus pneumoniae Haemophilus influenzae Tympanocentesis Antibiotic resistance AbbreviationsAOMAcute otitis media

ATPAccording to protocol

CIConfidence interval

ENTEar, nose and throat specialist

MEFMiddle ear fluid

PCV77-valent pneumococcal conjugate vaccine

TMTympanic membrane.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2334-12-312 contains supplementary material, which is available to authorized users.

An erratum to this article is available at http:-dx.doi.org-10.1186-s12879-016-1415-4.

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Author: Gerhard Grevers - Susanne Wiedemann - Jan-Christof Bohn - Rolf-Werner Blasius - Thomas Harder - Werner Kroeniger - Volker V

Source: https://link.springer.com/



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