Study of treatment using percutaneous acetabuloplasty and interstitial implantation of 125I seeds for patients with metastatic periacetabular tumorsReport as inadecuate




Study of treatment using percutaneous acetabuloplasty and interstitial implantation of 125I seeds for patients with metastatic periacetabular tumors - Download this document for free, or read online. Document in PDF available to download.

World Journal of Surgical Oncology

, 10:250

First Online: 20 November 2012Received: 09 June 2012Accepted: 31 October 2012

Abstract

BackgroundThe periacetabular area is one of the primary sites of metastatic tumors, which often present as osteolytic bone destruction. Bone destruction in the acetabulum caused by metastatic tumors will cause hip pain and joint dysfunction. It results in decreased quality of life for patients. The aim of our study was to explore the clinical effect of metastatic periacetabular tumors treated with percutaneous cementoplasty and interstitial implantation of I seeds.

MethodsA retrospective analysis was performed on 24 patients with metastatic periacetabular tumors who underwent combined therapy of percutaneous acetabuloplasty and interstitial implantation of I seeds between February 2003 and June 2011. There were 13 males and 11 females aged 19–80 years with a mean age of 57.3. The primary tumor site was the lung in eight cases, the breast in six, the prostate cancer in eight, and the liver in two. The amount of implanted I seeds was 12–20 seeds-person, with a mean of 16.5 seeds-person, and the matching peripheral dosage MPD was 80~100Gy. Routine postoperative chemotherapy and other combined treatments were applied to patients after the surgical operation. Changes in the Karnofsky ScoreKPS, Harris Hip ScoreHarris, and Visual Analog ScaleVAS were observed during the follow-up period.

ResultsThe 24 patients’ operations were all successful. No major complications occurred. Complete pain relief was achieved in 58% 14 of 24 of patients, and pain reduction was achieved in the 42% remaining 10 patients. The mean duration of pain relief was 8.3 months. Pain recurred in one patient 3 months after surgery. Six patients had died and 18 patients were alive at the time of the 1-year follow-up. Comparing the KPS, Harris and VAS scores pre- and postoperativelyat 1, 6, and 12 months, the combined therapy method was significantly effective in metastatic periacetabular tumor patients P<0.05.

ConclusionsPercutaneous cementoplasty with interstitial implantation of I seeds is an effective treatment method for metastatic periacetabular tumor patients, providing tumor resistance, pain relief, increased bone stability, and improved quality of life for patients.

KeywordsPeriacetabular Metastatic tumor I seed implantation Percutaneous acetabuloplasty Bone cement Electronic supplementary materialThe online version of this article doi:10.1186-1477-7819-10-250 contains supplementary material, which is available to authorized users.

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Author: Jinlei Zhang - Zuozhang Yang - Jiaping Wang - Jinde Wang - Pengjie Liu - Hongpu Sun - Kun Li - Yunshan Yang

Source: https://link.springer.com/







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