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BMC Infectious Diseases

, 12:330

Bacterial and fungal diseases

Abstract

BackgroundCritically ill patients including trauma patients are at high risk of urinary tract infection UTI. The composition of urine in trauma patients may be modified due to inflammation, systemic stress, rhabdomyolysis, life support treatment and-or urinary catheter insertion.

MethodsProspective, single-centre, observational study conducted in patients with severe trauma and without a history of UTIs or recent antibiotic treatment. The 24-hour urine samples were collected on the first and the fifth days and the growth of Escherichia coli in urine from patients and healthy volunteers was compared. Biochemical and hormonal modifications in urine that could potentially influence bacterial growth were explored.

ResultsGrowth of E. coli in urine from trauma patients was significantly higher on days 1 and 5 than in urine of healthy volunteers. Several significant modifications of urine composition could explain these findings. On days 1 and 5, trauma patients had an increase in glycosuria, in urine iron concentration, and in the concentrations of several amino acids compared to healthy volunteers. On day 1, the urinary osmotic pressure was significantly lower than for healthy volunteers.

ConclusionWe showed that urine of trauma patients facilitated growth of E. coli when compared to urine from healthy volunteers. This effect was present in the first 24 hours and until at least the fifth day after trauma. This phenomenon may be involved in the pathophysiology of UTIs in trauma patients. Further studies are required to define the exact causes of such modifications.

KeywordsNosocomial urinary tract infection Escherichia coli Bacterial growth Trauma patients Electronic supplementary materialThe online version of this article doi:10.1186-1471-2334-12-330 contains supplementary material, which is available to authorized users.

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Author: Cecile Aubron - Olivier Huet - Sylvie Ricome - Didier Borderie - Eric Pussard - Pierre-Etienne Leblanc - Odile Bouvet - Eri

Source: https://link.springer.com/



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