A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH FAAH C385A is associated with emotional–motivational reactivityReport as inadecuate




A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH FAAH C385A is associated with emotional–motivational reactivity - Download this document for free, or read online. Document in PDF available to download.

Psychopharmacology

, Volume 224, Issue 4, pp 573–579

First Online: 10 July 2012Received: 19 March 2012Accepted: 15 June 2012

Abstract

RationaleThe endocannabinoid eCB system is implicated in several psychiatric disorders. Investigating emotional–motivational dysfunctions as underlying mechanisms, a study in humans revealed that in the C385A polymorphism of the fatty acid amide hydrolase FAAH, the degrading enzyme of the eCB anandamide AEA, A carriers, who are characterized by increased signaling of AEA as compared to C-C carriers, exhibited reduced brain reactivity towards unpleasant faces and enhanced reactivity towards reward. However, the association of eCB system with emotional–motivational reactivity is complex and bidirectional due to upcoming compensatory processes.

ObjectivesTherefore, we further investigated the relationship of the FAAH polymorphism and emotional–motivational reactivity in humans.

MethodsWe assessed the affect-modulated startle, and ratings of valence and arousal in response to higher arousing pleasant, neutral, and unpleasant pictures in 67 FAAH C385AC-C carriers and 45 A carriers.

ResultsContrarily to the previous functional MRI study, A carriers compared to C-C carriers exhibited an increased startle potentiation and therefore emotional responsiveness towards unpleasant picture stimuli and reduced startle inhibition indicating reduced emotional reactivity in response to pleasant pictures, while both groups did not differ in ratings of arousal and valence.

ConclusionsOur findings emphasize the bidirectionality and thorough examination of the eCB system’s impact on emotional reactivity as a central endophenotype underlying various psychiatric disorders.

KeywordsFAAH Genetics Endocannabinoid Emotion Startle reflex Electronic supplementary materialThe online version of this article doi:10.1007-s00213-012-2785-y contains supplementary material, which is available to authorized users.

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Author: Annette Conzelmann - Andreas Reif - Christian Jacob - Peter Weyers - Klaus-Peter Lesch - Beat Lutz - Paul Pauli

Source: https://link.springer.com/



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