Risk of esophagus cancer in diabetes mellitus: a population-based case-control study in TaiwanReport as inadecuate




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BMC Gastroenterology

, 12:177

Gastroesophageal disorders

Abstract

BackgroundDiabetes mellitus DM has been associated with the cancer risk. This study investigated relationship between DM and esophageal cancer using Taiwan’s insurance data.

MethodsWe identified 549 patients with esophageal cancer newly diagnosed in 2000-2009 and randomly selected 2196 controls without any cancer, frequency matched by sex, age and diagnosis year of cases. Logistic regression model estimated odds ratios ORs and 95% confidence intervals CI of esophageal cancer associated with DM, sex, age. co-morbidities and medications.

ResultsCases were more prevalent than controls for alcoholism and esophageal disorders and using nonsteroidal anti-inflammatory drugs NSAIDs and cyclooxygenase-2 inhibitors but not DM. Esophageal cancer had no association with DM OR 0.99, 95% CI 0.71-1.37, but significantly associated with alcoholism OR 14.1, 95% CI 7.87-25.4, esophageal ulcer OR 10.1, 95% CI 5.70-17.9, esophageal reflux OR 3.47, 95% CI 2.14-5.26 and uses of NSAIDs OR 2.73, 95% CI 1.80-4.13. An elevated risk of esophageal cancer appeared in DM patients taking insulin OR 2.57, 95% CI 1.08-6.15 or sulfonyurea OR 3.80, 95% CI 1.16-12.5.

ConclusionsPatients with DM are not at higher risk for esophagus cancer. However, esophageal disorders and anti-diabetic drugs are associated with the risk of the disease.

KeywordsCase-control study Diabetes Esophagus cancer Insulin  Download fulltext PDF



Author: Kao-Chi Cheng - Yu-Lung Chen - Shih-Wei Lai - Pang-Yao Tsai - Fung-Chang Sung

Source: https://link.springer.com/



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