Constraint and cost of oxidative stress on reproduction: correlative evidence in laboratory mice and review of the literatureReport as inadecuate




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Frontiers in Zoology

, 9:37

First Online: 26 December 2012Received: 27 July 2012Accepted: 17 December 2012

Abstract

BackgroundOne central concept in evolutionary ecology is that current and residual reproductive values are negatively linked by the so-called cost of reproduction. Previous studies examining the nature of this cost suggested a possible involvement of oxidative stress resulting from the imbalance between pro- and anti-oxidant processes. Still, data remain conflictory probably because, although oxidative damage increases during reproduction, high systemic levels of oxidative stress might also constrain parental investment in reproduction. Here, we investigated variation in oxidative balance i.e. oxidative damage and antioxidant defences over the course of reproduction by comparing female laboratory mice rearing or not pups.

ResultsA significant increase in oxidative damage over time was only observed in females caring for offspring, whereas antioxidant defences increased over time regardless of reproductive status. Interestingly, oxidative damage measured prior to reproduction was negatively associated with litter size at birth constraint, whereas damage measured after reproduction was positively related to litter size at weaning cost.

ConclusionsGlobally, our correlative results and the review of literature describing the links between reproduction and oxidative stress underline the importance of timing-dynamics when studying and interpreting oxidative balance in relation to reproduction. Our study highlights the duality constraint and cost of oxidative stress in life-history trade-offs, thus supporting the theory that oxidative stress plays a key role in life-history evolution.

KeywordsLife-history trade-offs Reactive oxygen species Antioxidant Ageing Literature review Electronic supplementary materialThe online version of this article doi:10.1186-1742-9994-9-37 contains supplementary material, which is available to authorized users.

Pierre Bize and François Criscuolo contributed equally to this work.

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Author: Antoine Stier - Sophie Reichert - Sylvie Massemin - Pierre Bize - François Criscuolo

Source: https://link.springer.com/



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