Platelet glycoprotein Ibα is an important mediator of ischemic stroke in miceReport as inadecuate




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Experimental and Translational Stroke Medicine

, 3:9

First Online: 13 September 2011Received: 01 July 2011Accepted: 13 September 2011

Abstract

BackgroundPlatelets play an important role in ischemic stroke. GPIbα is a major platelet receptor that is critical for platelet adhesion to exposed subendothelial matrix components at sites of vascular damage.

MethodsIn this study, we used transgenic mice in which the extracellular part of GPIbα is replaced by human interleukin 4-receptor GPIbα-IL4Rα. We observed normal brain vasculature in these mice. We compared infarct size in GPIbα-IL4Rα and wild-type WT mice 23 hours after 1-hour transient middle cerebral artery occlusion tMCAO. In addition, the functional outcome was evaluated using a modified Bederson score.

ResultsWe found a significantly smaller infarct size in GPIbα-IL4Rα mice compared to WT mice 38.0 ± 6.5 mm vs. 74.2 ± 8.6 mm, p < 0.001. The decrease in infarct size was functionally relevant as indicated by a significantly better functional Bederson score in GPIbα-IL4Rα mice compared to WT animals 1.3 ± 0.4 vs. 2.7 ± 0.3, p < 0.05.

ConclusionsOur data illustrate and further confirm the important role of platelet GPIbα in ischemic stroke, suggesting that targeted inhibition of this receptor may open new avenues in stroke treatment.

Electronic supplementary materialThe online version of this article doi:10.1186-2040-7378-3-9 contains supplementary material, which is available to authorized users.

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Author: Simon F De Meyer - Tobias Schwarz - Daphne Schatzberg - Denisa D Wagner

Source: https://link.springer.com/



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