Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step backReport as inadecuate




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Radiation Oncology

, 6:115

First Online: 13 September 2011Received: 02 April 2011Accepted: 13 September 2011

Abstract

A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase MGMT-promoter methylation as well as isocitrate dehydrogenase IDH1-mutational status. Unexpectedly, overall survival or progression-free survival were not longer in the group with methylated MGMT-promoter as compared to patients without that methylation. IDH-1 mutations were significantly associated with increased overall survival.

KeywordsGlioblastoma radiation temozolomide MGMT IDH Electronic supplementary materialThe online version of this article doi:10.1186-1748-717X-6-115 contains supplementary material, which is available to authorized users.

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Author: Stephanie E Combs - Stefan Rieken - Wolfgang Wick - Amir Abdollahi - Andreas von Deimling - Jürgen Debus - Christian Hart

Source: https://link.springer.com/



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