Rising burden of Hepatitis C Virus in hemodialysis patientsReport as inadecuate




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Virology Journal

, 8:438

First Online: 13 September 2011Received: 14 July 2011Accepted: 13 September 2011

Abstract

AimHigh prevalence of Hepatitis C virus HCV has been reported among the dialysis patients throughout the world. No serious efforts were taken to investigate HCV in patients undergoing hemodialysis HD treatment who are at great increased risk to HCV. HCV genotypes are important in the study of epidemiology, pathogenesis and reaction to antiviral therapy. This study was performed to investigate the prevalence of active HCV infection, HCV genotypes and to assess risk factors associated with HCV genotype infection in HD patients of Khyber Pakhtunkhwa as well as comparing this prevalence data with past studies in Pakistan.

MethodsPolymerase chain reaction was performed for HCV RNA detection and genotyping in 384 HD patients. The data obtained was compared with available past studies from Pakistan.

ResultsAnti HCV antibodies were observed in 112 29.2%, of whom 90 80.4% were HCV RNA positive. In rest of the anti HCV negative patients, HCV RNA was detected in 16 5.9% patients. The dominant HCV genotypes in HCV infected HD patients were found to be 3a n = 36, 3b n = 20, 1a n = 16, 2a n = 10, 2b n = 2, 1b n = 4, 4a n = 2, untypeable n = 10 and mixed n = 12 genotype.

ConclusionThis study suggesting that i the prevalence of HCV does not differentiate between past and present infection and continued to be elevated ii HD patients may be a risk for HCV due to the involvement of multiple routes of infections especially poor blood screening of transfused blood and low standard of dialysis procedures in Pakistan and iii need to apply infection control practice.

KeywordsDialysis patients HCV HCV Genotype Epidemiology Pakistan Electronic supplementary materialThe online version of this article doi:10.1186-1743-422X-8-438 contains supplementary material, which is available to authorized users.

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Author: Sanaullah Khan - Sobia Attaullah - Ijaz Ali - Sultan Ayaz - Naseemullah - Shahid Niaz Khan - Sami Siraj - Jabbar Khan

Source: https://link.springer.com/







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