Molecular subtype analysis determines the association of advanced breast cancer in Egypt with favorable biologyReport as inadecuate




Molecular subtype analysis determines the association of advanced breast cancer in Egypt with favorable biology - Download this document for free, or read online. Document in PDF available to download.

BMC Women-s Health

, 11:44

First Online: 30 September 2011Received: 09 April 2011Accepted: 30 September 2011

Abstract

BackgroundPrognostic markers and molecular breast cancer subtypes reflect underlying biological tumor behavior and are important for patient management. Compared to Western countries, women in North Africa are less likely to be prognosticated and treated based on well-characterized markers such as the estrogen receptor ER, progesterone receptor PR and Her2. We conducted this study to determine the prevalence of breast cancer molecular subtypes in the North African country of Egypt as a measure of underlying biological characteristics driving tumor manifestations.

MethodsTo determine molecular subtypes we characterized over 200 tumor specimens obtained from Egypt by performing ER, PR, Her2, CK5-6, EGFR and Ki67 immunohistochemistry.

ResultsOur study demonstrated that the Luminal A subtype, associated with favorable prognosis, was found in nearly 45% of cases examined. However, the basal-like subtype, associated with poor prognosis, was found in 11% of cases. These findings are in sharp contrast to other parts of Africa in which the basal-like subtype is over-represented.

ConclusionsEgyptians appear to have favorable underlying biology, albeit having advanced disease at diagnosis. These data suggest that Egyptians would largely profit from early detection of their disease. Intervention at the public health level, including education on the benefits of early detection is necessary and would likely have tremendous impact on breast cancer outcome in Egypt.

KeywordsEgypt Breast Cancer subtypes ethnicity early detection Africa AbbreviationsANOVAanalysis of variance

ASRage-standardized rate

CK 5-6cytokeratin 5-6

EDTAEthylenediaminetetraacetic acid

EGFRepidermal growth factor receptor

ERestrogen receptor

FFPEformalin-fixed paraffin-embedded

Her2human epidermal growth factor receptor-2-positive

IHCimmunohistochemistry

MRMmodified radical mastectomy

NRYnon-recombining region of the Y chromosome

PRprogesterone receptor

TMAtissue microarray.

Electronic supplementary materialThe online version of this article doi:10.1186-1472-6874-11-44 contains supplementary material, which is available to authorized users.

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Author: Bodour Salhia - Coya Tapia - Elia A Ishak - Salwa Gaber - Bree Berghuis - Khateeb H Hussain - Rachelle A DuQuette - Jame

Source: https://link.springer.com/



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