Aberrant DNA methylation of drug metabolism and transport genes in nodular goiterReport as inadecuate




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Thyroid Research

, 4:15

First Online: 12 October 2011Received: 31 August 2011Accepted: 12 October 2011

Abstract

The genes encoding drug-metabolizing enzymes and transporters play an important role in maintaining the normal life processes of human body. Their disorder or defect will lead to the occurrence and development of various diseases. Currently, most of studies have focused on genetic variations in these genes, however, in the present study, we analyzed promoter methylation of 11 drug metabolism and transport genes in a cohort of nodular goiter and normal thyroid tissues using methylation-specific PCR MSP. Our data first revealed a distinct methylation profiling in drug metabolism and transport genes between nodular goiter and normal thyroid tissues, particularly ABCB4, CYP1B1 and CYP24A1 and SLC1A2. Given these genes contribute to the development and progression of various diseases, such as multidrug resistance and tumorigenesis, these epigenetic events may thus play a critical role in the pathogenesis of nodular goiter.

KeywordsNodular goiter Solute carrier SLC family Cytochrome P450 CYP family ATP binding cassette ABC family Drug metabolism and transport genes DNA methylation Electronic supplementary materialThe online version of this article doi:10.1186-1756-6614-4-15 contains supplementary material, which is available to authorized users.

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Author: Lihong Zhang - Jing Shi - Li Xu - Bingyin Shi - Peng Hou - Meiju Ji

Source: https://link.springer.com/







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