Habenula volume in post-traumatic stress disorder measured with high-resolution MRIReport as inadecuate

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Biology of Mood and Anxiety Disorders

, 1:7

First Online: 12 October 2011Received: 11 May 2011Accepted: 12 October 2011


BackgroundThe habenula plays an important role in regulating behavioral responses to stress and shows increased cerebral blood flow and decreased gray matter volume in patients with mood disorders. Here, we compare the volume of the habenula in unmedicated patients with post-traumatic stress disorder PTSD and healthy controls HC using MRI.

FindingsHigh-resolution images resolution of approximately 0.4 mm were acquired using a 3T scanner and a pulse sequence optimized for tissue contrast resolution. The habenula was manually segmented by one rater blind to diagnosis. PTSD and HC participants did not differ significantly in absolute or normalized habenula volume. Post hoc analyses controlling for the effects of comorbid major depressive disorder MDD and type and age of trauma exposure were not significant. Further, there was no association between PTSD severity and habenula volume.

ConclusionsOur data suggest that PTSD is not associated with robust structural changes in the habenula. The modest size of the PTSD sample may have reduced statistical power thereby accounting for the negative results obtained.

Electronic supplementary materialThe online version of this article doi:10.1186-2045-5380-1-7 contains supplementary material, which is available to authorized users.

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Author: Jonathan B Savitz - Omer Bonne - Allison C Nugent - Meena Vythilingam - Wendy Bogers - Dennis S Charney - Wayne C Dreve

Source: https://link.springer.com/

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