Surgical treatment for pulmonary metastases from esophageal carcinoma after definitive chemoradiotherapy: Experience from a single institutionReport as inadecuate




Surgical treatment for pulmonary metastases from esophageal carcinoma after definitive chemoradiotherapy: Experience from a single institution - Download this document for free, or read online. Document in PDF available to download.

Journal of Cardiothoracic Surgery

, 6:135

First Online: 12 October 2011Received: 28 May 2011Accepted: 12 October 2011

Abstract

BackgroundSurgical treatment for pulmonary metastases is known to be a safe and potentially curative procedure for various primary malignancies. However, there are few reports regarding the prognostic role of surgical treatment for pulmonary metastases from esophageal carcinoma, especially after definitive chemoradiotherapy CRT.

MethodsWe retrospectively reviewed 5 patients who underwent surgical treatment for pulmonary metastases from esophageal carcinoma at our institution. The primary treatment for esophageal carcinoma was definitive CRT, and a complete response CR was achieved in all patients.

ResultsThe surgical procedure for pulmonary metastases was wedge resection, and pathological complete resection was achieved in all 5 patients. The disease free interval after definitive CRT varied from 7 to 36 months, with a median of 19 months. There were no perioperative complications, but postoperative respiratory failure occurred in 1 patient. The postoperative hospital stay varied from 4 to 7 days, with a median of 6 days. Three patients are now alive with a good performance status PS and are disease free. The other 2 patients died of primary disease. The overall survival after surgical treatment varied from 20 to 90 months, with a median of 29 months.

ConclusionsSurgical treatment should be considered for patients with pulmonary metastases from esophageal carcinoma who previously received CRT and achieved a CR, because it provides not only a longer survival, but also a good postoperative PS for some patients.

Keywordsesophageal carcinoma definitive chemoradiotherapy complete response pulmonary metastases surgical treatment AbbreviationsCRTchemoradiotherapy

CRcomplete response

CTcomputed tomography

PSperformance status

DFIdisease free interval

OSoverall survival

Cecervical esophagus

Utupper thoracic esophagus

SCCsquamous cell carcinoma

DOCdocetaxel

PDprogressive disease.

Electronic supplementary materialThe online version of this article doi:10.1186-1749-8090-6-135 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Yoshiki Kozu - Hiroshi Sato - Yasuhiro Tsubosa - Hirofumi Ogawa - Hirofumi Yasui - Haruhiko Kondo

Source: https://link.springer.com/







Related documents