Low frequency of human papillomavirus infection in conjunctival squamous cell carcinoma of Mexican patientsReport as inadecuate




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Infectious Agents and Cancer

, 6:24

First Online: 18 November 2011Received: 13 September 2011Accepted: 18 November 2011

Abstract

BackgroundThe relationship between Human Papillomavirus HPV infection and conjunctiva cancer is controversial. HPV detection will provide more information about the role of this infectious agent in the biology of conjunctiva cancer. In the present study, DNA extracted and purified from 36 Conjunctival Squamous Cell Carcinomas CSCC was evaluated by PCR for HPV DNA sequences. The results were correlated with the clinical and histopathological variables.

ResultsThe results showed that HPV DNA was present in 8 CSCC samples 22%; HPV16 was the sole type detected. Significant association was found between HPV detection and the limbus tumor subtype p = 0.03. All the samples were non-metastatic squamous cell carcinoma.

ConclusionsThe HPV presence in CSCC from Mexican patients is not a common event.

Keywordsconjunctiva carcinoma HPV Electronic supplementary materialThe online version of this article doi:10.1186-1750-9378-6-24 contains supplementary material, which is available to authorized users.

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Author: Raúl Peralta - Alejandra Valdivia - Perla Estañol - Vanessa Villegas - Carolina Pimienta - Eugenio Treviño - Daniel Marr

Source: https://link.springer.com/



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