Inhibitory potential of omega-3 fatty and fenugreek essential oil on key enzymes of carbohydrate-digestion and hypertension in diabetes ratsReport as inadecuate




Inhibitory potential of omega-3 fatty and fenugreek essential oil on key enzymes of carbohydrate-digestion and hypertension in diabetes rats - Download this document for free, or read online. Document in PDF available to download.

Lipids in Health and Disease

, 10:226

First Online: 05 December 2011Received: 06 August 2011Accepted: 05 December 2011

Abstract

Backgrounddiabetes is a serious health problem and a source of risk for numerous severe complications such as obesity and hypertension. Treatment of diabetes and its related diseases can be achieved by inhibiting key digestives enzymes-related to starch digestion secreted by pancreas.

MethodsThe formulation omega-3 with fenugreek terpenenes was administrated to surviving diabetic rats. The inhibitory effects of this oil on rat pancreas α-amylase and maltase and plasma angiotensin-converting enzyme ACE were determined.

Resultsthe findings revealed that administration of formulation omega-3 with fenugreek terpenenes Om3-terp considerably inhibited key enzymes-related to diabetes such as α-amylase activity by 46 and 52% and maltase activity by 37 and 35% respectively in pancreas and plasma. Moreover, the findings revealed that this supplement helped protect the β-Cells of the rats from death and damage. Interestingly, the formulation Om3-terp modulated key enzyme related to hypertension such as ACE by 37% in plasma and kidney. Moreover administration of fenugreek essential oil to surviving diabetic rats improved starch and glucose oral tolerance additively. Furthermore, the Om3-terp also decreased significantly the glucose, triglyceride TG and total-cholesterol TC and LDL-cholesterol LDL-C rates in the plasma and liver of diabetic rats and increased the HDL-Cholesterol HDL-Ch level, which helped maintain the homeostasis of blood lipid.

Conclusionoverall, the findings of the current study indicate that this formulation Om3-terp exhibit attractive properties and can, therefore, be considered for future application in the development of anti-diabetic, anti-hypertensive and hypolipidemic foods.

Electronic supplementary materialThe online version of this article doi:10.1186-1476-511X-10-226 contains supplementary material, which is available to authorized users.

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Author: Khaled Hamden - Henda Keskes - Sahla Belhaj - Kais Mnafgui - Abdelfattah feki - Noureddine Allouche

Source: https://link.springer.com/







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