C-reactive protein levels: a prognostic marker for patients with head and neck cancerReport as inadecuate




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Head and Neck Oncology

, 2:21

First Online: 02 August 2010Received: 04 June 2010Accepted: 02 August 2010

Abstract

BackgroundRecent advances in understanding complex tumor interactions have led to the discovery of an association between inflammation and cancer, in particular for colon and lung cancer, but only a very few have dealt with oral cancer. Therefore, the aim of the current study was to investigate the significance of preoperative C-reactive protein CRP levels as a parameter for development of lymph node metastases or recurrence.

Materials and methodsIn 278 patients with oral cancer, preoperative CRP levels were compared with development of recurrence and metastasis.

ResultsIn 27 patients from the normal CRP group, and in 21 patients from the elevated CRP group, local recurrence was observed. Concerning lymph node metastases, 37 patients were in the normal group and 9 patients in the elevated CRP group. No significant correlation could be found between elevated CRP levels and metastasis p = 0.468 or recurrence p = 0.137.

ConclusionOur findings do not appear to support a correlation between preoperative CRP levels and development of recurrence or metastases. In further studies, CRP levels in precancerous lesions and in Human Papilloma Virus HPV positive patients with oral squamous cell carcinoma SCC should be studied.

Electronic supplementary materialThe online version of this article doi:10.1186-1758-3284-2-21 contains supplementary material, which is available to authorized users.

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Author: Astrid L Kruse - Heinz T Luebbers - Klaus W Grätz

Source: https://link.springer.com/



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