A Re-evaluation of the -Oncogenic- Nature of Wnt-β-catenin Signaling in Melanoma and Other CancersReport as inadecuate




A Re-evaluation of the -Oncogenic- Nature of Wnt-β-catenin Signaling in Melanoma and Other Cancers - Download this document for free, or read online. Document in PDF available to download.

Current Oncology Reports

, Volume 12, Issue 5, pp 314–318

First Online: 06 July 2010

Abstract

In cancer, Wnt-β-catenin signaling is ubiquitously referred to as an -oncogenic- pathway that promotes tumor progression. This review examines how the regulation and downstream effects of Wnt-β-catenin signaling in cancer varies depending on cellular context, with a focus on malignant melanoma. We emphasize that the cellular homeostasis of Wnt-β-catenin signaling may represent a more appropriate concept than the simplified view of the Wnt-β-catenin pathway as either oncogenic or tumor-suppressing. Ultimately, a more refined understanding of the contextual regulation of Wnt-β-catenin signaling will be essential for addressing if and how therapeutic targeting of this pathway could be leveraged for patient benefit.

KeywordsWnt Oncogene Melanoma Beta-catenin Homeostasis  Download fulltext PDF



Author: Olivia M. Lucero - David W. Dawson - Randall T. Moon - Andy J. Chien

Source: https://link.springer.com/







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