Treatment with a proton pump inhibitor improves glycaemic control in Psammomys obesus, a model of type 2 diabetesReport as inadecuate




Treatment with a proton pump inhibitor improves glycaemic control in Psammomys obesus, a model of type 2 diabetes - Download this document for free, or read online. Document in PDF available to download.

Diabetologia

, Volume 53, Issue 10, pp 2220–2223

First Online: 30 June 2010Received: 06 April 2010Accepted: 19 May 2010

Abstract

Aims-hypothesisGastrin has been implicated in islet growth-neogenesis, and proton pump inhibitors PPIs have been shown to increase endogenous gastrin levels in animals and humans. Therefore, we investigated the effect of PPIs in a model of type 2 diabetes, Psammomys obesus.

MethodsP. obesus morning blood glucose mBG 16.9 ± 0.6 mmol-l were treated with vehicle or different doses 1–15 mg-kg of lansoprazole for 17 days.

ResultsTreatment with lansoprazole resulted in up to ninefold dose-dependent increases in endogenous gastrin levels p < 0.05 for 10 mg-kg lansoprazole vs vehicle. There was a significant reduction in mBG levels in all animals in the high-dose lansoprazole groups during the 17 day treatment period, whereas there was no significant improvement in mBG in animals in the vehicle groups. The mBG at end of study was 18.2 ± 2.1, 8.7 ± 2.2 p < 0.01, and 6.1 ± 2.3 p < 0.001 mmol-l for vehicle and lansoprazole 10 and 15 mg-kg, respectively. The animals treated with 15 mg-kg lansoprazole, compared with vehicle, had a 2.3-fold increase in the intensity of insulin staining in beta cells p=0.0002 and 50% higher beta cell mass p=0.04.

Conclusions-interpretationsThe PPI lansoprazole had significant glucose-lowering effects in an animal model of type 2 diabetes, an effect that is most likely mediated through an increase in endogenous gastrin levels.

KeywordsAnimal model Beta cell mass Gastrin Glycaemic control Proton pump inhibitor Type 2 diabetes AbbreviationsBCMBeta cell mass

BWBody weight

mBGMorning blood glucose

PPIProton pump inhibitor

SPAScintillation proximity assay

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Author: T. B. Bödvarsdóttir - K. D. Hove - C. F. Gotfredsen - L. Pridal - A. Vaag - A. E. Karlsen - J. S. Petersen

Source: https://link.springer.com/



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