Amorphization of a crystalline active pharmaceutical ingredient and thermoanalytical measurements on this glassy formReport as inadecuate




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Journal of Thermal Analysis and Calorimetry

, Volume 102, Issue 1, pp 243–247

First Online: 05 November 2009Received: 30 June 2009Accepted: 29 September 2009

Abstract

Amorphization is nowadays a method that is frequently applied in the pharmaceutical industry. The primary aim of this study is to achieve the amorphization of clopidogrel hydrogen sulphate as an active pharmaceutical ingredient API with various solvents and to choose the most suitable one. A secondary aim was to determine the glass-transition temperature Tg of this API and to classify it as a good or poor glass former. To investigate the amorphous form, differential scanning calorimetry, X-ray powder diffraction, and FT-IR analysis were applied. The melting point Tm was 177.4 °C 450.6 K, and Tg was determined to be 88.9 °C 362.1 K. The quotient Tg-Tm was 0.80, and this API was therefore classified as a good glass former.

KeywordsAmorphization Clopidogrel hydrogen sulfate DSC FT-IR spectroscopy Solvent method Tg X-ray powder diffraction  Download fulltext PDF



Author: Orsolya Jójárt-Laczkovich - Piroska Szabó-Révész

Source: https://link.springer.com/







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