Acute Homeostatic Responses to Increased Fat Consumption in MCH1R Knockout MiceReport as inadecuate




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Journal of Molecular Neuroscience

, Volume 42, Issue 3, pp 459–463

First Online: 22 April 2010Received: 09 February 2010Accepted: 19 March 2010

Abstract

Melanin-concentrating hormone MCH is a hypothalamic neuropeptide which has been shown to regulate energy homeostasis. Using genetic knockout mice lacking the MCH1 receptor MCH1R, we investigated how these mice adapt to metabolic changes caused by excessive caloric consumption. We show that the MCH system is one of the players mediating behavioral and metabolic responses upon increased caloric consumption. MCH1R knockout mice showed decreased tendency of food intake upon exposure to a high-fat diet. They also are resistant to gain weight upon high-fat diet by increasing fat metabolism. Therefore, the MCH system is important in regulating metabolic responses upon various environmental stimuli such as high-fat diet.

KeywordsMelanin-concentrating hormone Energy homeostasis G protein-coupled receptor Neuropeptide  Download fulltext PDF



Author: Shinjae Chung - Timothy Wong - Hiroshi Nagasaki - Olivier Civelli

Source: https://link.springer.com/



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