ISS Flight 2A.2B (STS-106): Commercial Generic Bioprocessing Apparatus (CGBA) Payload BioServe Space TechnologiesReport as inadecuate




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The two experiments housed in the Commercial Generic Bioprocessing Apparatus (CGBA) during STS-106 were designed to explore how biological processes are affected by microgravity. The first was a developmental study into the effects of microgravity on motor-neuronal growth in the fruit fly species Drosophila melanogaster and the second study was des

Author: Stodieck, Louis; Klaus, Davi

Source: https://archive.org/


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Operational Accomplishments Report ISS Flight 2A.2B (STS-106) Commercial Generic Bioprocessing Apparatus (CGBA) Payload BioServe Space Technologies Department of Aerospace Engineering Sciences University of Colorado, Boulder, CO CGBA PI: Dr.
Louis Stodieck, Director Report Prepared By: Dr.
David Klaus, Associate Director Io Introduction m. Hypothesis The two experiments housed in the Commercial Generic Bioprocessing Apparatus (CGBA) during STS-106 were designed to explore how biological processes are affected by microgravity. The first was a developmental study into the effects of microgravity on motor-neuronal growth in the fruit fly species Drosophila melanogaster and the second study was designed to characterize changes in kidney cell gene expression. B° Objectives of the Investigation The objective of the primary experiment, called NIH-B1, was to determine how gravity affects neuronal development of the D.
melanogaster embryo and larvae in microgravity, specifically observing the neural connections to muscle fibers.
The PI is Dr.
Haig Kesheshian of Yale University. C° Previous Mission Experience STS-106 was the first successful flight for the NIH-B 1 experiment.
(It had previously flown on STS-93, but the science objectives were not accomplished due to an electrical anomaly with the payload.) The renal cell experiment had previously flown on the STS 90-Neurolab. Beginning with STS-50 in 1992, the CGBA payload has now flown in various configurations a total of 12 times onboard the shuttle (including STS-106) and has also resided on Mir twice during long-duration missions of approximately 4 months each.
For STS-106, the CGBA payload consisted of one Isothermal Containment Module, Version 3 (ICM v3).
The ICM v3 is a middeck locker insert that provides processing and independent thermal control for 8 experimental sample containers, with -l-liter of total volume in each, as shown with the lid open in Figure 1. Figure 1.
Commercial Generic Bioprocessing C...






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